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Changing your shower head could help improve sensitive skin, study suggests
In a nutshell
- Ultrafine bubble (UFB) showers significantly improved eczema symptoms in mice exposed to allergens, reducing inflammation and boosting key skin barrier proteins compared to regular water or no treatment.
- The treatment showed no major benefits in genetically driven eczema, suggesting UFB showers may be most effective for cases triggered by external allergens like dust mites.
- While the results are promising, the research was short-term and done in mice, so human studies are needed before UFB showers can be recommended as a treatment for atopic dermatitis.
OSAKA, Japan — For millions of people worldwide living with atopic dermatitis, the most common form of eczema, daily life means managing itchy, inflamed skin through medications, moisturizers, and careful bathing. Now, research from Japan suggests that simply changing your shower could make a real difference in managing this stubborn skin condition.
In a study published in Frontiers in Immunology, researchers from Osaka Metropolitan University discovered that showers containing ultrafine bubbles, tiny bubbles less than 1 micrometer in diameter, notably improved symptoms in mice with atopic dermatitis. These microscopic bubbles, already used to clean medical equipment, seem to help restore the skin’s protective barrier and decrease inflammation, especially in cases triggered by external allergens.
What Makes Ultrafine Bubble Showers Special?
Atopic dermatitis affects up to 20% of children and about 10% of adults globally. The condition features skin barrier problems, inflammation, and persistent itching. While medicine has developed many treatments targeting the immune system, dermatologists have always stressed that proper skin care, particularly bathing, remains essential to managing the condition.


The researchers emphasize that keeping the skin clean plays a crucial role in maintaining skin barrier function and preventing flare-ups. This advice has solid scientific support. Removing allergens, irritants, sweat, and microbes from the skin surface can stop flare-ups before they start.
Unlike regular bubbles, ultrafine bubbles are invisible to the naked eye, measuring between several tens to hundreds of nanometers in diameter. For comparison, these bubbles are smaller than most bacteria and about 1/100th the width of a human hair. These tiny bubbles have special physical properties that make them highly effective for cleaning without harsh detergents.
Promising Results in Mouse Studies
The research team tested ultrafine bubble showers on two different mouse models of atopic dermatitis. The first model used mice with dermatitis caused by house dust mite allergens that commonly trigger human atopic dermatitis. The second model used genetically modified mice that produce too much interleukin-33, a protein involved in allergic inflammation.
Each model included three groups: one treated with ultrafine bubble showers, another with normal water showers, and a control group that received no shower treatment. The researchers evaluated dermatitis severity scores, scratching behavior, skin tissue analysis, and measurements of inflammatory proteins and skin barrier components.
Mice receiving ultrafine bubble showers showed clearly improved skin appearance compared to both normal shower-treated mice and the untreated control group. This visible improvement was backed by measurable biological changes: lower levels of inflammatory proteins in the skin and higher expression of proteins essential for skin barrier function.


The ultrafine bubble shower treatment boosted several key skin barrier components, including proteins that form tight junctions between skin cells and maintain the skin’s protective outer layer. The treatment appears to work by thoroughly cleaning allergens from the skin while strengthening the skin barrier and reducing inflammation signals.
Interestingly, these benefits weren’t seen in the genetically modified mice. This indicates that ultrafine bubble showers may work best for atopic dermatitis cases triggered mainly by external allergens like dust mites, rather than forms driven mostly by genetic factors.
Potential for Human Application
The different responses between the two mouse models show something dermatologists have long known: atopic dermatitis isn’t a single disease but a range of related conditions with varying causes. This explains why treatments that help some patients may do little for others.
For people with allergen-triggered atopic dermatitis, ultrafine bubble technology could be a simple yet helpful addition to their treatment options. Unlike many treatments that require doctor visits or prescriptions, showering is already part of most people’s daily routine. Switching to an ultrafine bubble shower would require minimal lifestyle change while possibly offering significant relief.
The study’s authors believe that longer treatment periods might show even better results. Their experiment lasted only 7-14 days, but they suggest that extended ultrafine bubble shower treatment could improve additional symptoms like persistent scratching and skin thickening that didn’t change significantly during the brief study.
While human studies would be needed before making firm recommendations, this research shows promise for a simple, non-drug approach to managing certain types of atopic dermatitis. For eczema sufferers who’ve tried countless creams and medications, the idea that relief might come from something as basic as changing your shower head feels revolutionary.
Paper Summary
Methodology
Researchers used specialized shower heads to deliver one-minute daily ultrafine bubble or normal water treatments to mice with atopic dermatitis. The study examined two models: one with dermatitis induced by house dust mite allergens and another using mice genetically engineered to overproduce IL-33. Each model had three groups: ultrafine bubble shower, normal shower, and untreated controls. After treatment, skin samples were analyzed using various techniques to assess clinical symptoms, inflammation markers, and skin barrier components.
Results
In the dust mite-induced model, ultrafine bubble showers significantly improved clinical symptoms and dermatitis scores compared to untreated controls. Both ultrafine and normal showers reduced inflammatory cytokines IL-4 and IL-13. However, only the ultrafine bubble treatment significantly increased expression of skin barrier proteins, including claudin-1, Tmem79, and Kazrin at the mRNA level, plus filaggrin, loricrin, and involucrin at the protein level. The IL-33 transgenic mice showed minimal response to either shower type, suggesting ultrafine bubbles primarily benefit allergen-driven atopic dermatitis.
Limitations
This preliminary research has several key limitations. It was conducted on mice, not humans, with a relatively short treatment period of 7-14 days. Sample sizes were modest (4-15 mice per group). Benefits were only observed in allergen-induced dermatitis, not genetically-driven cases. The exact mechanisms by which ultrafine bubbles affect skin barrier proteins remain unclear. Human clinical trials with longer treatment periods would be needed to confirm potential benefits for patients.
Discussion and Takeaways
The study reveals that ultrafine bubble showers may offer a novel, non-pharmacological approach for managing allergen-triggered atopic dermatitis. By potentially enhancing skin barrier function while removing allergens, this technology addresses a fundamental aspect of atopic dermatitis pathophysiology. The differential response between mouse models suggests ultrafine bubble therapy might be most effective for extrinsic atopic dermatitis (triggered by external allergens) rather than intrinsic forms driven primarily by genetic factors. This reinforces the importance of personalized treatment approaches for different atopic dermatitis subtypes.
Funding and Disclosures
This research was supported by funding from Osaka city and Science Co., Ltd., which develops ultrafine bubble technology. One study author, Masateru Hirae, is employed by Science Co., Ltd., representing a potential conflict of interest. The remaining authors declared no commercial or financial relationships that could influence the study results.
Publication Information
The study, “Beneficial effects of ultrafine bubble shower on a mouse model of atopic dermatitis,” was published in Frontiers in Immunology on December 26, 2024. The research was led by Ayaki Matsumoto and Hisayoshi Imanishi from Osaka Metropolitan University in Japan. The article’s DOI is 10.3389/fimmu.2024.1483000, and RNA sequencing data is available in the DNA Data Bank of Japan under accession numbers DRR621560, DRR621561, and DRR621562.