MB PDX lines Ex vivo drug treatments, eVLP transduction and tandem-mass-tag (TMT)-proteomic study on PDXs were performed at St. Jude Children’s Research Hospital (SJCRH). NSG mice (NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ; The Jackson Laboratory, JAX catalogue no. 005557) were used